Cefsulodine sodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

头孢磺啶钠盐水合物是第三代β；内酰胺类抗生素，头孢烯类抗生素亚群的成员。

Cefsulodin sodium salt hydrate is a third generation β lactam antibiotic and member of the cephems subgroub of antibiotics.(In Vitro):Cefsulodin sodium (0.5-64 mg/mL; 18 h) is active in minimum inhibitory concentrations (MICs) of 0.5-64 mg/mL, is about 16- to 32-fold more active than Carbenicillin (HY-B0525) against Psuedomonas aeruginosa.Cefsulodin sodium (8-16 μg/mL; 4.5 h) is not hydrolyzed by the beta-lactamase induced in P. aeruginosa by growth in the presence of benzylpenicillin.(In Vivo):Cefsulodin sodium (1 g/kg/tag; i.p.; 5 d, 9 single doses with intervals of 12 h) shows a increasing excretion of tubule cells in the rat, as a measure of nephrotoxicity, and displays tubule toxic threshold doses of 250 mg/kg (s.c.; 12 d) with nine single doses.

Cefsulodin sodium (0.5-64 mg/mL; 18 h) is active in minimum inhibitory concentrations (MICs) of 0.5-64 mg/mL, is about 16- to 32-fold more active than Carbenicillin (HY-B0525) against Psuedomonas aeruginosa.Cefsulodin sodium (8-16 μg/mL; 4.5 h) is not hydrolyzed by the beta-lactamase induced in P. aeruginosa by growth in the presence of benzylpenicillin.

Cefsulodin sodium (1 g/kg/tag; i.p.; 5 d, 9 single doses with intervals of 12 h) shows a increasing excretion of tubule cells in the rat, as a measure of nephrotoxicity, and displays tubule toxic threshold doses of 250 mg/kg (s.c.; 12 d) with nine single doses. Animal Model:Female Wistar rats (200 g)Dosage:1000 mg/kg/tag Administration:Intraperitoneal injection; 5 days; nine single doses, with intervals of 12 h (injection volume: 10 mL)Result:Increased in excretion of tubule cells in the 12-hour night urine during five-day treatment.

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52152-93-9

554.52

C22H19N4NaO8S2

>98% (HPLC)

DMSO: 10 mM

O=C(C(N12)=C(C[N+]3=CC=C(C(N)=O)C=C3)CS[C@]2([H])[C@H](NC([C@@H](C4=CC=CC=C4)S(=O)([O-])=O)=O)C1=O)[O-].[Na+]

sodium (6R,7R)-3-((4-carbamoylpyridin-1-ium-1-yl)methyl)-8-oxo-7-((R)-2-phenyl-2-sulfonatoacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(-20℃)

With Ice Pack

≥ 2 years